Serum glycoprotein levels during wound tissue regeneration.

The level of protein-bound hexoses was compared in several fractions of electrophoretically separated globulins in the sera of normal and wounded rats. Changes in the concentration of protein components which were not apparent from the amount of total protein of different fractions could be identified. Although wounding resulted in no change from the normal protein level of one a-globulin fraction, the proteinbound hexoses decreased significantly below the normal. In another a-globulin fraction from wounded animals, a parallel increase in both protein and hexose above the normal was observed. The total proteins in the fl-globulin fraction were not affected by wounding, even though there was an appreciable increase in hexose in the wounded over the normal level. In spite of the marked decrease in the amount of protein in the y-globulins of wounded rats, no significant difference in the hexoses associated with this fraction was observed. Other globulin fractions were unchanged during wound tissue regeneration.